Small molecule crystallography
Sometimes referred to as chemical crystallography, this technique employs single crystal X-ray diffraction (SXRD) to unambiguously determine the three dimensional structure of small molecules. Such compounds, which may be of both chemical and biological interest, include new synthetic chemicals, catalysts, pharmaceuticals, and natural products.
Once a crystal of the material under investigation has been grown to suitable size, the complete diffraction pattern—which may consist of thousands of individual measurements—resulting from the interaction of an intense X-ray beam with the crystal is collected, typically on an area detector that can collect a large number of observations in a single exposure.
Automated structure solution is accomplished by analysis of the complex diffraction pattern. This same technique can also be used to produce detailed electron density maps of molecular bonds.
Rigaku offers a complete range of small molecule instrumentation solutions: the benchtop SCXmini™ and XtaLAB mini™, the powerful and unique RAPID II, Saturn and Mercury CCD detectors and the customizable HomeLab™ line.
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