Analysis of a complex chemical compound
On the basis of the chemical principle of carbonic anhydrase (CA)-aromatic sulfonamide inhibitor interaction, a dansylamidoethyl-pendant cyclen(1-(2-(5-(dimethylamino)-1-naphthalenesulfonamido)ethyl)-1,4,7,10-tetraazacyclododecane, HL) was synthesized as a novel type of zinc(II)-fluorophore. The new ligand forms very stable complexes with zinc(II), cadmium(II), and copper(II) at physiological pH. The X-ray crystal study of the Zn complex disclosed a five-coordinate, distorted square-pyramidal structure with the deprotonated dansylamide N-coordinating at the apical site.
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Reference: |
T. Koike, T. Watanabe, S. Aoki, E. Kimura, M. Shiro, A Novel Biomimetic Zinc(II)-Fluorophore, Dansylamidoethyl-Pendant Macrocyclic Tetraamine 1,4,7,10-Tetraazacyclododecane (Cyclen), J. Am. Chem. Soc. (1996) 118, 12696-12703 [abstract] |
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Formula: |
C22H35N6O6SClZn |
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Formula weight: |
612.45 |
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Crystal size: |
0.45 × 0.25 × 0.20 mm |
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Space group: |
Pna21 |
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Unit cell: |
a=23.777(3) Å |
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Radiation: |
CuKα |
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Data collection temperature: |
296K |
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Source: |
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Detector: |
Data provided by Professor Shin Aoki, Tokyo University of Science, Faculty of Pharmaceutical Sciences
